Infarcted Adenomatoid Tumour of Epididymis: A Rare Case Report
Infarcted Adenomatoid Tumour of Epididymis: A Rare Case Report
A. Gupta,1 M. Livingston,1 R. Singh,1 D. Tansey,1,2 and L. Solomon1
1Urology Department, Queen Alexandra Hospital, Southwick Road, Cosham, Portsmouth PO6 3LY, UK
2Histopathology Department, Queen Alexandra Hospital, Southwick Road, Cosham, Portsmouth PO6 3LY, UK
Received 18 January 2013; Accepted 18 March 2013
Academic Editors: F. Bruyere, K.-S. Lee, G. Lombardi, and J. Palou-Redorta
Copyright © 2013 A. Gupta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Paratesticular tumours are pathologically rare. The vast majority are benign in nature with adenomatoid tumours representing the most common pathological entity. We present the case of a 32-year-old man, from the Indian subcontinent, who presented with a painful scrotal swelling sustained after trauma. The history suggested that the scrotal mass had been present for approximately 12 months, and a preliminary diagnosis of a haemorrhagic cyst caused by trauma was made. Initial management included scrotal support, analgesia, and a follow-up magnetic resonance imaging (MRI) scan. Subsequent imaging and then further histological analysis confirmed a partly necrotic/infarcted adenomatoid tumour of the right epididymis. After scrotal exploration and epididymectomy, the patient made a complete recovery, and, with the histological diagnosis, he was discharged with no further followup. The case is presented as a learning point in the identification and management of such pathologies.
1. Introduction
Paratesticular tumours are pathologically rare. The vast majority are benign in nature with adenomatoid tumours representing the most common pathological entity [1]. The predeliction of paratesticular adenomatoid tumours for men in their 3rd-4th decade of life makes them difficult to be differentiated clinically and radiologically from other more sinister intrascrotal pathology and therefore presents a diagnostic challenge [2]. We present a case that highlights this diagnostic dilemma.
2. Case Report
A 32-year-old man form the Indian subcontinent presented to the emergency department 2 days after having been kicked in the scrotum during a football match with increasing pain and swelling of the right hemiscrotum. A firm discrete mass was noted at the lower pole of the right epididymis that was clinically inseparable from the otherwise unremarkable testicle. The right testicle was nontender and sat in a normal position with no signs of scrotal skin ecchymosis. The history suggested that the scrotal mass had been present for approximately 12 months, and a preliminary diagnosis of a haemorrhagic cyst caused by trauma was made. Initial management included scrotal support, analgesia, and a follow-up magnetic resonance imaging (MRI) scan. The MRI confirmed a 2.3 cm irregular lesion arising posterior to the lower pole of the right testis that enhanced peripherally with central necrosis and therefore could not rule out a potentially malignant lesion (Figure 1(a)). After informed consent, a scrotal exploration and epididymectomy was performed. Grossly, the specimen measured 25 mm in maximum diameter. Sectioning revealed a 20 mm yellow, partly necrotic tumour mass (Figure 1(b)).
fig1
Figure 1: (a) Cross-sectional MRI shows peripheral enhancement of the lesion, which is clearly separate from the testis and demonstrates a central area of necrosis. (b) Cut surface of the specimen shows a yellow tumour mass with central necrosis.
Histological examination (H+E) showed a central area of coagulative necrosis with surrounding reactive fibroblastic tissue and inflammation (Figure 2). Irregular clusters and solid nests of viable epithelioid cells were present, partly obscured by the fibroblastic tissue reaction (Figure 3).
937689.fig.002
Figure 2: Coagulative necrosis in the central part of the tumour.
937689.fig.003
Figure 3: Irregular nests of viable neoplastic cells.
On immunohistochemical staining, these epithelioid cells were positive for CAM5.2 and CK7 and also expressed the mesothelial markers calretinin and WT1 (Figure 4). The H+E appearances and immunoprofile were consistent with a partly necrotic/infarcted adenomatoid tumour. No evidence of malignancy was seen. The tumour was well circumscribed and completely excised at all margins. The patient was informed of the results, reassured, and discharged from further followup.
937689.fig.004
Figure 4: Positive calretinin staining in the neoplastic cells.
3. Discussion
Paratesticular neoplasms are rare and account for less than 10% of all intrascrotal tumours [3]. Epididymal tumours are a rare subtype of paratesticular neoplasms with the majority being benign in nature. Adenomatoid neoplasms represent the most common histological variant followed by leiomyoma and then papillary cystadenoma with other rarer lesions including angioma, lipoma, dermoid cysts, fibroma, hamartoma, teratoma, and cholesteatoma making up the remainder. Adenomatoid tumours can be found in a variety of locations including the spermatic cord, prostate, ejaculatory ducts, and scrotal capes. In females, they can be located in the uterus, Fallopian tubes, and ovarian area [4], Only 25% of all epididymal neoplasms are found to be malignant with the most common subtype being sarcoma (45%) and the rest comprising metastatic deposits and primary epididymal carcinomas. Epididymal adenomatoid tumours are commonly present in the 3rd or 4th decade of life as a painless small lump, but they can occur at any age and can vary in size [5]. Traumatic infarction is an unusual presentation but it was first described in the literature by de Klerk and Nime in 1975 [6]. Since then, there have been a small number of case reports highlighting the diagnostic dilemma that infracted adenomatoid tumours present, but there is no consensus on how to investigate and manage them. This case represents another example of a rare presentation of this tumour. In our view, even though malignant causes are rare, there should always be a high index of suspicion when assessing and managing patients presenting with scrotal masses, and prompt multidisciplinary discussion to dictate investigations and interventions is essential.
References
M. T. Kuhn and G. T. MacLennan, “Benign neoplasms of the epididymis,” Journal of Urology, vol. 174, no. 2, article 723, 2005. View at Publisher · View at Google Scholar · View at Scopus
M. A. Maestro, R. T. González, J. M. A. Dorrego, J. de la Peña Barthel, and M. N. M. de Serrano, “Adenomatoid tumors of the epididymis and testicle: report of 9 cases and bibliographic review,” Archivos Espanoles de Urologia, vol. 62, no. 2, pp. 137–141, 2009. View at Google Scholar · View at Scopus
G. Broth, W. K. Bullock, and J. Morrow, “Epididymal tumors. 1. Report of 15 new cases including review of literature. 2. Histochemical study of the so-called adenomatoid tumor,” Journal of Urology, vol. 100, no. 4, pp. 530–536, 1968. View at Google Scholar · View at Scopus
S. Kontos, I. Fokitis, A. Karakosta et al., “Adenomatoid tumor of epididymis: a case report,” Cases Journal, vol. 1, article 206, 2008. View at Publisher · View at Google Scholar
A. A. Samad, B. Pereiro, A. Badiola, C. Gallego, and E. Zungri, “Adenomatoid tumor of intratesticular localization,” European Urology, vol. 30, no. 1, pp. 127–128, 1996. View at Google Scholar · View at Scopus
D. P. de Klerk and F. Nime, “Adenomatoid tumors (mesothelioma) of testicular and paratesticular tissue,” Urology, vol. 6, no. 5, pp. 635–641, 1975. View at Google Scholar · View at Scopus
A. Gupta,1 M. Livingston,1 R. Singh,1 D. Tansey,1,2 and L. Solomon1
1Urology Department, Queen Alexandra Hospital, Southwick Road, Cosham, Portsmouth PO6 3LY, UK
2Histopathology Department, Queen Alexandra Hospital, Southwick Road, Cosham, Portsmouth PO6 3LY, UK
Received 18 January 2013; Accepted 18 March 2013
Academic Editors: F. Bruyere, K.-S. Lee, G. Lombardi, and J. Palou-Redorta
Copyright © 2013 A. Gupta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Paratesticular tumours are pathologically rare. The vast majority are benign in nature with adenomatoid tumours representing the most common pathological entity. We present the case of a 32-year-old man, from the Indian subcontinent, who presented with a painful scrotal swelling sustained after trauma. The history suggested that the scrotal mass had been present for approximately 12 months, and a preliminary diagnosis of a haemorrhagic cyst caused by trauma was made. Initial management included scrotal support, analgesia, and a follow-up magnetic resonance imaging (MRI) scan. Subsequent imaging and then further histological analysis confirmed a partly necrotic/infarcted adenomatoid tumour of the right epididymis. After scrotal exploration and epididymectomy, the patient made a complete recovery, and, with the histological diagnosis, he was discharged with no further followup. The case is presented as a learning point in the identification and management of such pathologies.
1. Introduction
Paratesticular tumours are pathologically rare. The vast majority are benign in nature with adenomatoid tumours representing the most common pathological entity [1]. The predeliction of paratesticular adenomatoid tumours for men in their 3rd-4th decade of life makes them difficult to be differentiated clinically and radiologically from other more sinister intrascrotal pathology and therefore presents a diagnostic challenge [2]. We present a case that highlights this diagnostic dilemma.
2. Case Report
A 32-year-old man form the Indian subcontinent presented to the emergency department 2 days after having been kicked in the scrotum during a football match with increasing pain and swelling of the right hemiscrotum. A firm discrete mass was noted at the lower pole of the right epididymis that was clinically inseparable from the otherwise unremarkable testicle. The right testicle was nontender and sat in a normal position with no signs of scrotal skin ecchymosis. The history suggested that the scrotal mass had been present for approximately 12 months, and a preliminary diagnosis of a haemorrhagic cyst caused by trauma was made. Initial management included scrotal support, analgesia, and a follow-up magnetic resonance imaging (MRI) scan. The MRI confirmed a 2.3 cm irregular lesion arising posterior to the lower pole of the right testis that enhanced peripherally with central necrosis and therefore could not rule out a potentially malignant lesion (Figure 1(a)). After informed consent, a scrotal exploration and epididymectomy was performed. Grossly, the specimen measured 25 mm in maximum diameter. Sectioning revealed a 20 mm yellow, partly necrotic tumour mass (Figure 1(b)).
fig1
Figure 1: (a) Cross-sectional MRI shows peripheral enhancement of the lesion, which is clearly separate from the testis and demonstrates a central area of necrosis. (b) Cut surface of the specimen shows a yellow tumour mass with central necrosis.
Histological examination (H+E) showed a central area of coagulative necrosis with surrounding reactive fibroblastic tissue and inflammation (Figure 2). Irregular clusters and solid nests of viable epithelioid cells were present, partly obscured by the fibroblastic tissue reaction (Figure 3).
937689.fig.002
Figure 2: Coagulative necrosis in the central part of the tumour.
937689.fig.003
Figure 3: Irregular nests of viable neoplastic cells.
On immunohistochemical staining, these epithelioid cells were positive for CAM5.2 and CK7 and also expressed the mesothelial markers calretinin and WT1 (Figure 4). The H+E appearances and immunoprofile were consistent with a partly necrotic/infarcted adenomatoid tumour. No evidence of malignancy was seen. The tumour was well circumscribed and completely excised at all margins. The patient was informed of the results, reassured, and discharged from further followup.
937689.fig.004
Figure 4: Positive calretinin staining in the neoplastic cells.
3. Discussion
Paratesticular neoplasms are rare and account for less than 10% of all intrascrotal tumours [3]. Epididymal tumours are a rare subtype of paratesticular neoplasms with the majority being benign in nature. Adenomatoid neoplasms represent the most common histological variant followed by leiomyoma and then papillary cystadenoma with other rarer lesions including angioma, lipoma, dermoid cysts, fibroma, hamartoma, teratoma, and cholesteatoma making up the remainder. Adenomatoid tumours can be found in a variety of locations including the spermatic cord, prostate, ejaculatory ducts, and scrotal capes. In females, they can be located in the uterus, Fallopian tubes, and ovarian area [4], Only 25% of all epididymal neoplasms are found to be malignant with the most common subtype being sarcoma (45%) and the rest comprising metastatic deposits and primary epididymal carcinomas. Epididymal adenomatoid tumours are commonly present in the 3rd or 4th decade of life as a painless small lump, but they can occur at any age and can vary in size [5]. Traumatic infarction is an unusual presentation but it was first described in the literature by de Klerk and Nime in 1975 [6]. Since then, there have been a small number of case reports highlighting the diagnostic dilemma that infracted adenomatoid tumours present, but there is no consensus on how to investigate and manage them. This case represents another example of a rare presentation of this tumour. In our view, even though malignant causes are rare, there should always be a high index of suspicion when assessing and managing patients presenting with scrotal masses, and prompt multidisciplinary discussion to dictate investigations and interventions is essential.
References
M. T. Kuhn and G. T. MacLennan, “Benign neoplasms of the epididymis,” Journal of Urology, vol. 174, no. 2, article 723, 2005. View at Publisher · View at Google Scholar · View at Scopus
M. A. Maestro, R. T. González, J. M. A. Dorrego, J. de la Peña Barthel, and M. N. M. de Serrano, “Adenomatoid tumors of the epididymis and testicle: report of 9 cases and bibliographic review,” Archivos Espanoles de Urologia, vol. 62, no. 2, pp. 137–141, 2009. View at Google Scholar · View at Scopus
G. Broth, W. K. Bullock, and J. Morrow, “Epididymal tumors. 1. Report of 15 new cases including review of literature. 2. Histochemical study of the so-called adenomatoid tumor,” Journal of Urology, vol. 100, no. 4, pp. 530–536, 1968. View at Google Scholar · View at Scopus
S. Kontos, I. Fokitis, A. Karakosta et al., “Adenomatoid tumor of epididymis: a case report,” Cases Journal, vol. 1, article 206, 2008. View at Publisher · View at Google Scholar
A. A. Samad, B. Pereiro, A. Badiola, C. Gallego, and E. Zungri, “Adenomatoid tumor of intratesticular localization,” European Urology, vol. 30, no. 1, pp. 127–128, 1996. View at Google Scholar · View at Scopus
D. P. de Klerk and F. Nime, “Adenomatoid tumors (mesothelioma) of testicular and paratesticular tissue,” Urology, vol. 6, no. 5, pp. 635–641, 1975. View at Google Scholar · View at Scopus
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